The defending champions have a juicy matchup as well, with Georgia hosting Oregon at Mercedes-Benz Stadium in Atlanta. RELATED: Best Big 12 Pregame College Football Stadium Experiences It’s only the third-ever trip for the Fighting Irish to the Horseshoe, and the Buckeyes are favored on betting apps by more than two touchdowns despite failing to reach the College Football Playoff in 2021. This year’s opening weekend slate features a historic matchup with Notre Dame taking on Ohio State in Columbus for the first time since 1995, and the college football week 1 odds have the Buckeyes as big favorites. You never really know what to expect until the stands are packed and the players hit the field. ![]() ![]() Week 1 in college football is always an incredibly exciting time – the marquee nonconference matchups are dialed in based on past accomplishments, but roster turnover, coaching changes and the transfer portal can make a huge impact from year-to-year. ![]() Sure, Week 0 was great, but this is where the real fun begins. College football betting is finally back after an excruciating seven-month absence, with Georgia fans basking in the glow of a national championship and successful bettors longing for the days of endless kickoffs and nonstop gridiron action.
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